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Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum
The single Fgf8 gene in mice produces eight protein isoforms (Fgf8a–h) with different N-termini by alternative splicing. Gain-of-function studies have demonstrated that Fgf8a and Fgf8b have distinct activities in the developing midbrain and hindbrain (MHB) due to their different binding affinities w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2815264/ https://ncbi.nlm.nih.gov/pubmed/19968985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.11.034 |
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