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Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation

The vertebrate Fgf8 gene produces multiple protein isoforms by alternative splicing. Two evolutionarily conserved spliceforms, Fgf8a and Fgf8b, exhibit distinct bioactivities, with Fgf8b having a more potent inductive activity due to higher affinity for Fgf receptors. To investigate the in vivo requ...

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Detalhes bibliográficos
Main Authors: Guo, Qiuxia, Li, James Y.H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518685/
https://ncbi.nlm.nih.gov/pubmed/17507393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.004929
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