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Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation

The vertebrate Fgf8 gene produces multiple protein isoforms by alternative splicing. Two evolutionarily conserved spliceforms, Fgf8a and Fgf8b, exhibit distinct bioactivities, with Fgf8b having a more potent inductive activity due to higher affinity for Fgf receptors. To investigate the in vivo requ...

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書誌詳細
主要な著者: Guo, Qiuxia, Li, James Y.H.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518685/
https://ncbi.nlm.nih.gov/pubmed/17507393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.004929
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