Pulsatile GnRH secretion: Roles of G protein-coupled receptors, second messengers and ion channels

The pulsatile secretion of GnRH from normal and immortalized hypothalamic GnRH neurons is highly calcium-dependent and is stimulated by cAMP. It is also influenced by agonist activation of the endogenous GnRH receptor (GnRH-R), which couples to multiple G proteins. This autocrine mechanism could ser...

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Bibliographic Details
Main Authors: Krsmanovic, Lazar Z., Hu, Lian, Leung, Po-Ki, Feng, Hao, Catt, Kevin J.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815227/
https://ncbi.nlm.nih.gov/pubmed/19486924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2009.05.015
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