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The Kynurenine Pathway in Adolescent Depression: Preliminary Findings from a Proton MR Spectroscopy Study
BACKGROUND: Cytokine induction of the enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in the development of major depressive disorder (MDD). IDO metabolizes tryptophan (TRP) into kynurenine (KYN), thereby decreasing TRP availability to the brain. KYN is further metabolized into several...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2815014/ https://ncbi.nlm.nih.gov/pubmed/19778568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pnpbp.2009.09.015 |
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