ER-α36, a Variant of ER-α, Promotes Tamoxifen Agonist Action in Endometrial Cancer Cells via the MAPK/ERK and PI3K/Akt Pathways

BACKGROUND: Recently, a novel variant of ER-α, ER-α36 was identified and cloned. ER-α36 lacks intrinsic transcription activity and mainly mediates nongenomic estrogen signaling. Here, we studied the role of nongenomic estrogen signaling pathways mediated by ER-α36 in tamoxifen resistance and agonist...

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Autores principales: Lin, Sheng-Li, Yan, Li-Ying, Zhang, Xin-Tian, Yuan, Ju, Li, Mo, Qiao, Jie, Wang, Zhao-Yi, Sun, Qing-Yuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814868/
https://ncbi.nlm.nih.gov/pubmed/20126312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009013
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