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Genomic Study of Replication Initiation in Human Chromosomes Reveals the Influence of Transcription Regulation and Chromatin Structure on Origin Selection

DNA replication in metazoans initiates from multiple chromosomal loci called origins. Currently, there are two methods to purify origin-centered nascent strands: lambda exonuclease digestion and anti-bromodeoxyuridine immunoprecipitation. Because both methods have unique strengths and limitations, w...

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Библиографические подробности
Главные авторы: Karnani, Neerja, Taylor, Christopher M., Malhotra, Ankit, Dutta, Anindya
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814785/
https://ncbi.nlm.nih.gov/pubmed/19955211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0707
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