Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

Phosphodiesterase (PDE) is a critical regulator of cAMP/protein kinase A (PKA) signaling in cells. Multiple PDEs with different substrate specificities and subcellular localization are expressed in neurons. Dopamine plays a central role in the regulation of motor and cognitive functions. The effect...

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Autors principals: Nishi, Akinori, Kuroiwa, Mahomi, Miller, Diane B., O'Callaghan, James P., Bateup, Helen S., Shuto, Takahide, Sotogaku, Naoki, Fukuda, Takaichi, Heintz, Nathaniel, Greengard, Paul, Snyder, Gretchen L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814340/
https://ncbi.nlm.nih.gov/pubmed/18923023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2518-08.2008
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