High-Dose Lovastatin for Acute Ischemic Stroke: Results of the Phase I Dose Escalation Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART)

BACKGROUND: Hydroxymethylglutaryl coenzyme A reductase inhibitors (‘statins’) reduce the neuronal injury in dose-dependent fashion in rodent stroke models. We sought to determine whether lovastatin at doses above those currently approved can be administered safely within 24 h after an acute ischemic...

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Bibliografiske detaljer
Main Authors: Elkind, Mitchell S.V., Sacco, Ralph L., MacArthur, Robert B., Peerschke, Ellinor, Neils, Greg, Andrews, Howard, Stillman, Joshua, Corporan, Tania, Leifer, Dana, Liu, Rui, Cheung, Ken
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2009
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814015/
https://ncbi.nlm.nih.gov/pubmed/19609078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000228709
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