Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse

BACKGROUND: Mutations in ATP8B1 (FIC1) underlie cases of cholestatic disease, ranging from chronic and progressive (progressive familial intrahepatic cholestasis) to intermittent (benign recurrent intrahepatic cholestasis). The ATP8B1-deficient mouse serves as an animal model of human ATP8B1 deficie...

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Detalhes bibliográficos
Main Authors: Shah, Sohela, Sanford, Ukina R., Vargas, Julie C., Xu, Hongmei, Groen, Annamiek, Paulusma, Coen C., Grenert, James P., Pawlikowska, Ludmila, Sen, Saunak, Elferink, Ronald P. J. Oude, Bull, Laura N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813882/
https://ncbi.nlm.nih.gov/pubmed/20126555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008984
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