Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection.

Both Pseudomonas aeruginosa elastase and Bacillus thermoproteolyticus thermolysin are zinc metalloproteases. On the basis of the high homology of the P. aeruginosa elastase with the Bacillus thermolysin, we hypothesized that Glu-141 and His-223 are the key residues for catalytic activity of the Pseu...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Kawamoto, S, Shibano, Y, Fukushima, J, Ishii, N, Morihara, K, Okuda, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8454342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.4.1400-1405.1993
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