Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection.

Both Pseudomonas aeruginosa elastase and Bacillus thermoproteolyticus thermolysin are zinc metalloproteases. On the basis of the high homology of the P. aeruginosa elastase with the Bacillus thermolysin, we hypothesized that Glu-141 and His-223 are the key residues for catalytic activity of the Pseu...

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Pubblicato in:	Infect Immun
Autori principali:	Kawamoto, S, Shibano, Y, Fukushima, J, Ishii, N, Morihara, K, Okuda, K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8454342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.4.1400-1405.1993
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