Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression

BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC) is a multi-faceted protein-modulating cell–cell and cell–matrix interactions. In cancer, SPARC can be not only associated with a highly aggressive phenotype, but also acts as a tumour suppressor. The aim of this study was to characteri...

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Detalhes bibliográficos
Main Authors: Chen, G, Tian, X, Liu, Z, Zhou, S, Schmidt, B, Henne-Bruns, D, Bachem, M, Kornmann, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813737/
https://ncbi.nlm.nih.gov/pubmed/19920824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605440
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