Lovastatin inhibits Oxidized- L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-Stimulated Interleukin-8 mRNA and Protein Synthesis in Human Aortic Endothelial Cells by Depleting Stores of Geranylgeranyl Pyrophosphate

Human aortic endothelial cells (HAEC) exposed to 50 μg/ml oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC) for 6 hours increased in interleukin-8 mRNA and protein levels. Preincubation of HAEC with the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) inhibitor, (20 μM), signi...

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Main Authors: Dvoracek, Lucas A., Kreisberg, Jeffrey I., McKinney, Jordan, Schmid, Gabrielle, Francis, Amanda D., Kacmarik, Katie L., Lee, Huey Miin, Detrick, Melinda S., Primerano, Donald A, Santanam, Nalini, Kreisberg, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813419/
https://ncbi.nlm.nih.gov/pubmed/19595352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2009.06.013
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