Upregulation of xCT by KSHV-Encoded microRNAs Facilitates KSHV Dissemination and Persistence in an Environment of Oxidative Stress

Upregulation of xCT, the inducible subunit of a membrane-bound amino acid transporter, replenishes intracellular glutathione stores to maintain cell viability in an environment of oxidative stress. xCT also serves as a fusion-entry receptor for the Kaposi's sarcoma-associated herpesvirus (KSHV)...

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Main Authors: Qin, Zhiqiang, Freitas, Eduardo, Sullivan, Roger, Mohan, Sarumathi, Bacelieri, Rocky, Branch, Drake, Romano, Margaret, Kearney, Patricia, Oates, Jim, Plaisance, Karlie, Renne, Rolf, Kaleeba, Johnan, Parsons, Chris
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813276/
https://ncbi.nlm.nih.gov/pubmed/20126446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000742
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