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Kinetics and Mechanism of Protein Tyrosine Phosphatase 1B (PTP1B) Inactivation by Acrolein

Human cells are exposed to the electrophilic α,β-unsaturated aldehyde acrolein from a variety of sources. Reaction of acrolein with functionally critical protein thiol residues can yield important biological consequences. Protein tyrosine phosphatases (PTPs) are an important class of cysteine-depend...

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Autori principali: Seiner, Derrick R., LaButti, Jason N., Gates, Kent S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812896/
https://ncbi.nlm.nih.gov/pubmed/17655273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700213s
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