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Inactivation of Protein Tyrosine Phosphatases by Oltipraz and Other Cancer Chemopreventive 1,2-Dithiole-3-thiones
Dithiolethiones upregulate the expression of cancer-preventive proteins via modification of thiol residues in the Keap1-Nrf2 transcription factor complex. In addition to Keap1-Nrf2, dithiolethiones have the potential to modify a variety of cysteine-containing proteins in the cell. Such “off target”...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253851/ https://ncbi.nlm.nih.gov/pubmed/20655236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.084 |
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