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Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model.

Alpha-2-macroglobulin (alpha 2M) may function as a proteinase inhibitor in vivo. Levels of this protein are decreased in sepsis, but the reason these levels are low is unknown. Therefore, we analyzed the behavior of alpha 2M in a baboon model for sepsis. Upon challenge with a lethal (4 baboons) or a...

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Detalhes bibliográficos
Main Authors: de Boer, J P, Creasey, A A, Chang, A, Abbink, J J, Roem, D, Eerenberg, A J, Hack, C E, Taylor, F B
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC281280/
https://ncbi.nlm.nih.gov/pubmed/7693593
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