Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons

In adult stroke models, 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP), a sigma receptor agonist, attenuates activity of neuronal nitric oxide synthase (nNOS), blunts ischemia-induced nitric oxide production, and provides neuroprotection. Here, we tested the hypothesis that PPBP attenuates neuronal da...

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Main Authors: Yang, Zeng-Jin, Carter, Erin L., Torbey, Michel T., Martin, Lee J., Koehler, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812675/
https://ncbi.nlm.nih.gov/pubmed/19883643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.10.019
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