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Intramolecular Oxamidation of Unsaturated O-Alkyl Hydroxamates: A Remarkably Versatile Entry to Hydroxy Lactams

The development of a versatile method for the preparation of 5 to 8-membered hydroxy lactams, involving the iodine(III)-mediated oxamidation of unsaturated O-alkyl hydroxamates is described. This transformation, which is believed to proceed through the intermediacy of singlet nitrenium and bicyclic...

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Autori principali: Wardrop, Duncan J., Bowen, Edward G., Forslund, Raymond E., Sussman, Adam D., Weerasekera, Samanthi L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812663/
https://ncbi.nlm.nih.gov/pubmed/19788297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9069997
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