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Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences

CD8(+) cytotoxic T lymphocyte (CTL)–mediated immune responses to HIV contribute to viral control in vivo. Epitopes encoded by alternative reading frame (ARF) peptides may be targeted by CTLs as well, but their frequency and in vivo relevance are unknown. Using host genetic (human leukocyte antigen [...

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Bibliografische gegevens
Hoofdauteurs: Berger, Christoph T., Carlson, Jonathan M., Brumme, Chanson J., Hartman, Kari L., Brumme, Zabrina L., Henry, Leah M., Rosato, Pamela C., Piechocka-Trocha, Alicja, Brockman, Mark A., Harrigan, P. Richard, Heckerman, David, Kaufmann, Daniel E., Brander, Christian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812535/
https://ncbi.nlm.nih.gov/pubmed/20065065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091808
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