Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients

PURPOSE: Non-melanoma skin cancer incidence is enhanced over fifty fold in patients taking anti-rejection drugs (ARDs) following organ transplantation. Pre-clinical studies suggest that ARD treatment increases transforming growth factor β1 (TGF-β1) levels, which contribute to enhanced tumor suscepti...

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Bibliographic Details
Main Authors: Harradine, Kelly A., Ridd, Katie, Saunier, Elise F., Clermont, Frederic F., Perez-Losada, Jesus, Moore, Dan H., Epstein, Ervin H., Bastian, Boris C., Akhurst, Rosemary J.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812428/
https://ncbi.nlm.nih.gov/pubmed/19671862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-3286
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