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Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel

The epothilones are naturally occurring, cytotoxic macrolides that function through a paclitaxel (Taxol)-like mechanism. Although structurally dissimilar, both classes of molecules lead to the arrest of cell division and eventual cell death by stabilizing cellular microtubule assemblies. The epothil...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Chou, Ting-Chao, Zhang, Xiu-Guo, Harris, Christina R., Kuduk, Scott D., Balog, Aaron, Savin, Kenneth A., Bertino, Joseph R., Danishefsky, Samuel J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28124/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9861050/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15798
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