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Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus Vpx

Vpx and Vpr are related lentiviral accessory proteins that enhance virus replication in macrophages and dendritic cells. Both proteins are packaged into virions and mediate their effects in the target cell through an interaction with an E3 ubiquitin ligase that contains DCAF1 and DDB1. When introduc...

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Bibliographic Details
Main Authors: Gramberg, Thomas, Sunseri, Nicole, Landau, Nathaniel R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812310/
https://ncbi.nlm.nih.gov/pubmed/19923175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01437-09
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