Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. W...

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Detalhes bibliográficos
Main Authors: Kasprowicz, Victoria, Kang, Yu-Hoi, Lucas, Michaela, Schulze zur Wiesch, Julian, Kuntzen, Thomas, Fleming, Vicki, Nolan, Brian E., Longworth, Steven, Berical, Andrew, Bengsch, Bertram, Thimme, Robert, Lewis-Ximenez, Lia, Allen, Todd M., Kim, Arthur Y., Klenerman, Paul, Lauer, Georg M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812309/
https://ncbi.nlm.nih.gov/pubmed/19906915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01499-09
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