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Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization

Filopodia are dynamic structures found at the leading edges of most migrating cells. IRSp53 plays a role in filopodium dynamics by coupling actin elongation with membrane protrusion. IRSp53 is a Cdc42 effector protein that contains an N-terminal inverse-BAR (Bin-amphipysin-Rvs) domain (IRSp53/MIM ho...

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Detalhes bibliográficos
Main Authors: Robens , Jeffrey M., Yeow-Fong, Lee, Ng, Elsa, Hall, Christine, Manser, Ed
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812224/
https://ncbi.nlm.nih.gov/pubmed/19933840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01574-08
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