Alanine Mutagenesis of the Primary Antigenic Escape Residue Cluster, C1, of Apical Membrane Antigen 1

Antibodies against apical membrane antigen 1 (AMA1) inhibit invasion of Plasmodium merozoites into red cells, and a large number of single nucleotide polymorphisms on AMA1 allow the parasite to escape inhibitory antibodies. The availability of a crystal structure makes it possible to test protein en...

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Detalhes bibliográficos
Main Authors: Dutta, Sheetij, Dlugosz, Lisa S., Clayton, Joshua W., Pool, Christopher D., Haynes, J. David, Gasser, Robert A., Batchelor, Adrian H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812209/
https://ncbi.nlm.nih.gov/pubmed/19948834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00866-09
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