Panel of Prototypical Raltegravir-Resistant Infectious Molecular Clones in a Novel Integrase-Deleted Cloning Vector

We created an HIV-1 cloning vector, pNL4.3ΔIN, to generate recombinant infectious molecular clones for analysis of patient-derived HIV-1 integrase coding regions. Using this vector, we constructed a panel of clinically derived viruses with the canonical patterns of raltegravir resistance mutations a...

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Detalles Bibliográficos
Autores principales: Reuman, Elizabeth C., Bachmann, Michael H., Varghese, Vici, Fessel, W. Jeffrey, Shafer, Robert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812164/
https://ncbi.nlm.nih.gov/pubmed/19917747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01345-09
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