Nicotine Exacerbates Brain Edema during In Vitro and In Vivo Focal Ischemic Conditions

We have previously shown that nicotine, the addictive component of tobacco products, alters the blood-brain barrier (BBB) Na(+),K(+),2Cl(−) cotransporter (NKCC) during in vitro hypoxia-aglycemia exposure. Attenuation of abluminal NKCC suggests that accumulation of ions in the brain extracellular flu...

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Detalhes bibliográficos
Main Authors: Paulson, Jennifer R., Yang, Tianzhi, Selvaraj, Pradeep K., Mdzinarishvili, Alexander, Van der Schyf, Cornelis J., Klein, Jochen, Bickel, Ulrich, Abbruscato, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812118/
https://ncbi.nlm.nih.gov/pubmed/19889792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.157776
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