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Photocrosslinking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct
Nucleotide excision repair (NER) is the main pathway used for the repair of bulky DNA adducts such as those caused by UV light exposure and the chemotherapeutic drug cisplatin. The Xeroderma Pigmentosum group C (XPC)-Rad23B complex is involved in the recognition of these bulky DNA adducts and initia...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811759/ https://ncbi.nlm.nih.gov/pubmed/20028083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901575h |
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