Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction

Cystic fibrosis (CF) is a lethal genetic disorder characterized by airway remodeling and inflammation, leading to premature death. Recent evidence suggests the importance of protease activity in CF pathogenesis. One prominent protease, matrix metalloprotease (MMP)-9, demonstrates increased activity...

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Bibliografiske detaljer
Main Authors: Jackson, Patricia L, Xu, Xin, Wilson, Landon, Weathington, Nathaniel M, Clancy, John Paul, Blalock, James Edwin, Gaggar, Amit
Format: Artigo
Sprog:Inglês
Udgivet: ScholarOne 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811559/
https://ncbi.nlm.nih.gov/pubmed/20111696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00109
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