Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

Modifying the length of the Huntington's disease (HD) CAG repeat, the major determinant of age of disease onset, is an attractive therapeutic approach. To explore this we are investigating mechanisms of intergenerational and somatic HD CAG repeat instability. Here, we have crossed HD CAG knock-...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Dragileva, Ella, Hendricks, Audrey, Teed, Allison, Gillis, Tammy, Lopez, Edith T, Friedberg, Errol C, Kucherlapati, Raju, Edelmann, Winfried, Lunetta, Kathryn L, MacDonald, Marcy E, Wheeler, Vanessa C
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811282/
https://ncbi.nlm.nih.gov/pubmed/18930147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.09.014
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares