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Activation of GABA-A Receptor Ameliorates Homocysteine-Induced MMP-9 Activation by ERK Pathway

Hyperhomocysteinemia (HHcy) is a risk factor for neuroinflammatory and neurodegenerative diseases. Homocysteine (Hcy) induces redox stress, in part, by activating matrix metalloproteinase-9 (MMP-9), which degrades the matrix and leads to blood–brain barrier dysfunction. Hcy competitively binds to γ-...

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Bibliografiske detaljer
Main Authors: TYAGI, NEETU, GILLESPIE, WILLIAM, VACEK, JONATHAN C., SEN, UTPAL, TYAGI, SURESH C., LOMINADZE, DAVID
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811271/
https://ncbi.nlm.nih.gov/pubmed/19308943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21757
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