Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients

BACKGROUND: Myeloproliferative disorders are characterized by clonal expansion of normal mature blood cells. Acquired mutations giving rise to constitutive activation of the JAK2 tyrosine kinase has been shown to be present in the majority of patients. Since the demonstration that the V617F mutation...

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Main Authors: Ugo, Valerie, Tondeur, Sylvie, Menot, Marie-Laurence, Bonnin, Nadine, Le Gac, Gerald, Tonetti, Carole, Mas, Veronique Mansat-De, Lecucq, Lydie, Kiladjian, Jean-Jacques, Chomienne, Christine, Dosquet, Christine, Parquet, Nathalie, Darnige, Luc, Porneuf, Marc, Escoffre-Barbe, Martine, Giraudier, Stephane, Delabesse, Eric, Cassinat, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811183/
https://ncbi.nlm.nih.gov/pubmed/20126644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008893
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