Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients

BACKGROUND: Myeloproliferative disorders are characterized by clonal expansion of normal mature blood cells. Acquired mutations giving rise to constitutive activation of the JAK2 tyrosine kinase has been shown to be present in the majority of patients. Since the demonstration that the V617F mutation...

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Detaylı Bibliyografya
Asıl Yazarlar: Ugo, Valerie, Tondeur, Sylvie, Menot, Marie-Laurence, Bonnin, Nadine, Le Gac, Gerald, Tonetti, Carole, Mas, Veronique Mansat-De, Lecucq, Lydie, Kiladjian, Jean-Jacques, Chomienne, Christine, Dosquet, Christine, Parquet, Nathalie, Darnige, Luc, Porneuf, Marc, Escoffre-Barbe, Martine, Giraudier, Stephane, Delabesse, Eric, Cassinat, Bruno
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811183/
https://ncbi.nlm.nih.gov/pubmed/20126644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008893
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