NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation

In megakaryocytes, the maturation process and oxidative stress response appear to be closely related. It has been suggested that increased oxygen tension and reactive oxygen species (ROS) promote megakaryopoiesis and that the expression of stress-responsive genes responsible for ROS elimination decl...

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Detalhes bibliográficos
Main Authors: Motohashi, Hozumi, Kimura, Momoko, Fujita, Rie, Inoue, Ai, Pan, Xiaoqing, Takayama, Mariko, Katsuoka, Fumiki, Aburatani, Hiroyuki, Bresnick, Emery H., Yamamoto, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810977/
https://ncbi.nlm.nih.gov/pubmed/19901266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-223107
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