Design, Synthesis and Biological Evaluations of 2,5-Diaryl-2,3-dihydro-1,3,4-oxadiazoline Analogs of Combretastatin-A4

Twenty-four novel 2,5-diaryl-1,3,4-oxadiazoline analogs of combretastatin A-4 (CA-4, 1) were designed, synthesized and evaluated for biological activities. The compounds represent two structural classes; the Type I class has three methoxy groups on the A ring and the Type II class has a single metho...

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Main Authors: Lee, Lauren, Robb, Lyda M., Lee, Megan, Davis, Ryan, Mackay, Hilary, Chavda, Sameer, Babu, Balaji, O’Brien, Erin L., Risinger, April L., Mooberry, Susan L., Lee, Moses
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810428/
https://ncbi.nlm.nih.gov/pubmed/19894742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901268n
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