Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis

Studies have demonstrated that B cells play important roles in systemic sclerosis (SSc), especially through the CD19/CD22 autoimmune loop. CD22 is a B cell-specific inhibitory receptor that dampens B cell antigen receptor (BCR) signalling via tyrosine phosphorylation-dependent mechanism. In this stu...

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Dettagli Bibliografici
Autori principali: Odaka, M, Hasegawa, M, Hamaguchi, Y, Ishiura, N, Kumada, S, Matsushita, T, Komura, K, Sato, S, Takehara, K, Fujimoto, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
Soggetti:
Translational Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810386/
https://ncbi.nlm.nih.gov/pubmed/19919568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2009.04059.x
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