Mutational Analysis of Highly Conserved Residues in the Phage PhiC31 Integrase Reveals Key Amino Acids Necessary for the DNA Recombination

BACKGROUND: Amino acid sequence alignment of phage phiC31 integrase with the serine recombinases family revealed highly conserved regions outside the catalytic domain. Until now, no system mutational or biochemical studies have been carried out to assess the roles of these conserved residues in the...

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Bibliographic Details
Main Authors: Liu, Shaohui, Ma, Jinfang, Wang, Wei, Zhang, Maoxiang, Xin, Qingting, Peng, Siman, Li, Rongxiu, Zhu, Huanzhang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810336/
https://ncbi.nlm.nih.gov/pubmed/20111606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008863
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