Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using (89)Zr-DFO-Trastuzumab

BACKGROUND: The positron-emitting radionuclide (89)Zr (t (1/2) = 3.17 days) was used to prepare (89)Zr-radiolabeled trastuzumab for use as a radiotracer for characterizing HER2/neu-positive breast tumors. In addition, pharmacodynamic studies on HER2/neu expression levels in response to therapeutic d...

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Bibliografiske detaljer
Main Authors: Holland, Jason P., Caldas-Lopes, Eloisi, Divilov, Vadim, Longo, Valerie A., Taldone, Tony, Zatorska, Danuta, Chiosis, Gabriela, Lewis, Jason S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810330/
https://ncbi.nlm.nih.gov/pubmed/20111600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008859
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