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Integration of BMP and Wnt Signaling via vertebrate Smad1/5/8 and Drosophila Mad
BMPs pattern the dorsal-ventral axis of vertebrate embryos. Smad1/5/8 transduces the BMP signal, and receives phosphorylation inputs from both MAPK and GSK3. Phosphorylation of Smad1 by MAPK and GSK3 result in its polyubiquitination and transport to the centrosome where it is degraded by the proteas...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810204/ https://ncbi.nlm.nih.gov/pubmed/19896409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cytogfr.2009.10.017 |
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