Targeting the Fatty Acid Biosynthesis Enzyme, β-Ketoacyl–Acyl Carrier Protein Synthase III (PfKASIII), in the Identification of Novel Antimalarial Agents

The importance of fatty acids to the human malaria parasite, Plasmodium falciparum, and differences due to a type I fatty acid synthesis (FAS) pathway in the parasite, make it an attractive drug target. In the present study, we developed and a utilized a pharmacophore to select compounds for testing...

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Main Authors: Lee, Patricia J., Bhonsle, Jayendra B., Gaona, Heather W., Huddler, Donald P., Heady, Tiffany N., Kreishman-Deitrick, Mara, Bhattacharjee, Apurba, McCalmont, William F., Gerena, Lucia, Lopez-Sanchez, Miriam, Roncal, Norma E., Hudson, Thomas H., Johnson, Jacob D., Prigge, Sean T., Waters, Norman C.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810129/
https://ncbi.nlm.nih.gov/pubmed/19191586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8008103
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