Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer

BACKGROUND: Mutations in the alpha catalytic subunit of phosphoinositol-3-kinase (PIK3CA) occur in ~30% of ER positive breast cancers. We therefore sought to determine the impact of PIK3CA mutation on response to neoadjuvant endocrine therapy. METHODS: Exon 9 (helical domain - HD) and Exon 20 (kinas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ellis, Matthew J, Lin, Li, Crowder, Robert, Tao, Yu, Hoog, Jeremy, Snider, Jacqueline, Davies, Sherri, DeSchryver, Katherine, Evans, Dean B, Steinseifer, Jutta, Bandaru, Raj, Liu, WeiHua, Gardner, Humphrey, Semiglazov, Vladimir, Watson, Mark, Hunt, Kelly, Olson, John, Baselga, José
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810126/
https://ncbi.nlm.nih.gov/pubmed/19844788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0575-y
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