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Akt Phosphorylation of Merlin Enhances its Binding to Phosphatidylinositols and Inhibits Tumor Suppressive Activities of Merlin

The NF2 tumor suppressor gene encodes an intracellular membrane-associated protein, called merlin, which belongs to the band 4.1 family of cytoskeleton-associated proteins that link cell surface glycoproteins to actin cytoskeleton. Merlin suppresses PI 3-kinase/Akt signaling through directly binding...

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Bibliografiske detaljer
Main Authors: Okada, Masashi, Wang, Yanru, Jang, Sung-Wuk, Tang, Xiaoling, Neri, Luca M., Ye, Keqiang
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810124/
https://ncbi.nlm.nih.gov/pubmed/19351837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3931
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