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Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

Neurofibromatosis 2 (NF2) is a tumor suppressor, although the molecular mechanism accounting for this effect remains unknown. Here, we show that merlin exerts its activity by inhibiting phosphatidylinositol 3-kinase (PI3-kinase), through binding to PIKE-L. Wild-type merlin, but not patient-derived m...

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Detalhes bibliográficos
Main Authors: Rong, Rong, Tang, Xiaoling, Gutmann, David H., Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC535703/
https://ncbi.nlm.nih.gov/pubmed/15598747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405971102
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