Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells

Trimethylation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) regulates the balance between self-renewal and differentiation of embryonic stem cells (ESCs). The mechanisms by which the activity and recruitment of PRC2 are controlled are largely unknown. Here we demonstrat...

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Detalhes bibliográficos
Main Authors: Shen, Xiaohua, Kim, Woojin, Fujiwara, Yuko, Simon, Matthew D., Liu, Yingchun, Mysliwiec, Matthew R., Yuan, Guo-Cheng, Lee, Youngsook, Orkin, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810107/
https://ncbi.nlm.nih.gov/pubmed/20064376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.12.003
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