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Evolutionary Mirages: Selection on Binding Site Composition Creates the Illusion of Conserved Grammars in Drosophila Enhancers

The clustering of transcription factor binding sites in developmental enhancers and the apparent preferential conservation of clustered sites have been widely interpreted as proof that spatially constrained physical interactions between transcription factors are required for regulatory function. How...

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Библиографические подробности
Главные авторы: Lusk, Richard W., Eisen, Michael B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809757/
https://ncbi.nlm.nih.gov/pubmed/20107516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000829
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