Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Current therapeutics and prophylactics for malaria are under severe challenge as a result of the rapid emergence of drug-resistant parasites. The human malaria parasite Plasmodium falciparum expresses two neutral aminopeptidases, PfA-M1 and PfA-M17, which function in regulating the intracellular poo...

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Hlavní autoři: McGowan, Sheena, Oellig, Christine A., Birru, Woldeamanuel A., Caradoc-Davies, Tom T., Stack, Colin M., Lowther, Jonathan, Skinner-Adams, Tina, Mucha, Artur, Kafarski, Pawel, Grembecka, Jolanta, Trenholme, Katharine R., Buckle, Ashley M., Gardiner, Donald L., Dalton, John P., Whisstock, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809755/
https://ncbi.nlm.nih.gov/pubmed/20133789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911813107
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