Functional consequences of the human leptin receptor (LEPR) Q223R transversion

Perturbations in the functional integrity of the leptin axis are obvious candidates for mediation of altered adiposity. In a large number of genetic association studies in humans, the non-conservative LEPR Q223R allele has been inconsistently associated with adiposity. Subtle, long term effects of s...

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Main Authors:	Stratigopoulos, George, LeDuc, Charles A., Matsuoka, Naoki, Gutman, Roee, Rausch, Richard, Robertson, Scott A., Myers, Martin G, Chung, Wendy K, Chua, Streamson C., Leibel, Rudolph L.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2008
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2808713/ https://ncbi.nlm.nih.gov/pubmed/18997673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oby.2008.489
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Functional consequences of the human leptin receptor (LEPR) Q223R transversion

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