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Association Thermodynamics and Conformational Stability of β-Sheet Amyloid β(17-42) Oligomers: Effects of E22Q (Dutch) Mutation and Charge Neutralization

Amyloid fibrils are associated with many neurodegenerative diseases. It was found that amyloidogenic oligomers, not mature fibrils, are neurotoxic agents related to these diseases. Molecular mechanisms of infectivity, pathways of aggregation, and molecular structure of these oligomers remain elusive...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Blinov, Nikolay, Dorosh, Lyudmyla, Wishart, David, Kovalenko, Andriy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Biophysical Society 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808487/
https://ncbi.nlm.nih.gov/pubmed/20338850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.062
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