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Association Thermodynamics and Conformational Stability of β-Sheet Amyloid β(17-42) Oligomers: Effects of E22Q (Dutch) Mutation and Charge Neutralization

Amyloid fibrils are associated with many neurodegenerative diseases. It was found that amyloidogenic oligomers, not mature fibrils, are neurotoxic agents related to these diseases. Molecular mechanisms of infectivity, pathways of aggregation, and molecular structure of these oligomers remain elusive...

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Detalles Bibliográficos
Main Authors: Blinov, Nikolay, Dorosh, Lyudmyla, Wishart, David, Kovalenko, Andriy
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808487/
https://ncbi.nlm.nih.gov/pubmed/20338850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.09.062
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