Bioenergetic metabolites regulate base excision repair dependent cell death in response to DNA damage

Base excision repair (BER) protein expression is important for resistance to DNA damage-induced cytotoxicity. Conversely, BER imbalance (Polß deficiency or repair inhibition) enhances cytotoxicity of radiation and chemotherapeutic DNA-damaging agents. Whereas inhibition of critical steps in the BER...

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Bibliografische gegevens
Hoofdauteurs: Tang, Jiang-bo, Goellner, Eva M., Wang, Xiao-hong, Trivedi, Ram N., Croix, Claudette M. St, Jelezcova, Elena, Svilar, David, Brown, Ashley R., Sobol, Robert W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808464/
https://ncbi.nlm.nih.gov/pubmed/20068071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0411
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